| EAGLE | : | European Association for Grey Literature Exploitation |
| EBLIDA | : | European Bureau of Library, Information and Documentation Associations |
| EC | : | Expansive Classification |
| ECHO | : | European Commission Host Organization |
| EDI | : | Electronic Data Interchange |
| EDSAC | : | Electronic Delay Storage Automatic Computer |
| EGA | : | Extended Graphic Adopter |
| EIIA | : | European Information Industry Association |
| EIRENE | : | European Information Researchers Network |
| ELBS | : | Educational Low-priced Books Scheme |
| ENIAC | : | Electronic Numerical Integration and Calculator |
| ENVIS | : | Environment Information System |
| EPIDOS | : | European Patent Information and Documentation Systems |
| EPLA | : | East Pakistan Library Association |
| EPO | : | European Patent Office |
| EPROM | : | Erasable Programmable Read Only Memory |
| ERIC | : | Educational Resource Information Center |
| ERNET | : | Education and Research Network |
| EROMM | : | European Register of Microform Masters |
| ES | : | Expert Systems |
| ESAIRS | : | European Space Agency Information Retrieval Service |
| ESPRIT | : | European Strategic Programme for Research in Information Technologies |
| ESRC | : | Economic and Social Research Council |
| ESTC | : | Eighteenth-century Short-Title Catalogue |
| ESTC-NA | : | Eighteenth-century Short-Title Catalogue North America |
| ETC | : | European Translation Center |
| ETS | : | European Telecommunications Standards |
| EU | : | European Union |
| EUCLID | : | European Conference of Library and Information Departments |
| EUNET | : | European Network |
| EUSIDIC | : | European Association of Information Services |